The big back-rower takes on Argentina in the Mandela Tribute match on Saturday.
Van Niekerk was nearly lost to Springbok rugby when he signed a contract with Saints last year, but the Franklin's Gardens club pulled out of the deal citing medical concerns.
The disappointment did not stop the Springbok from signing to play for a French club, Toulon, for a year.
"I'm looking forward to teaming up with (All Black) Jerry Collins. He's a monster."
Van Niekerk will remain available to play for South Africa. "I don't know about the regulations but the way I understand it, players can be called upon for certain matches.
"If the call comes I'll always be ready to play for the Springboks."
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